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Methylamino-PEG4-acid HCl

Names

[ CAS No. ]:
1283658-71-8

[ Name ]:
Methylamino-PEG4-acid HCl

[Synonym ]:
5,8,11,14-Tetraoxa-2-azaheptadecan-17-oic acid
MFCD28064328

Biological Activity

[Description]:

Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
405.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H25NO6

[ Molecular Weight ]:
279.330

[ Flash Point ]:
199.1±27.3 °C

[ Exact Mass ]:
279.168182

[ LogP ]:
-1.62

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.458

Related Compounds