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3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinocytidine

Names

[ CAS No. ]:
128495-99-8

[ Name ]:
3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinocytidine

[Synonym ]:
2(1H)-Pyrimidinone, 4-amino-1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
MFCD25542521
4-Amino-1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-2(1H)-pyrimidinone

Biological Activity

[Description]:

3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
617.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H20FN3O6

[ Molecular Weight ]:
453.42

[ Flash Point ]:
327.1±34.3 °C

[ Exact Mass ]:
453.133606

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.643

Related Compounds