Demethylcantharidate disodium

Names

[ CAS No. ]:
129-67-9

[ Name ]:
Demethylcantharidate disodium

[Synonym ]:
disodium 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate
disodium demethylcantharate
endothal
disodium,7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate
endothal-sodium
Disodium endothall
disodium endothallate
Accelerate
Endothal-sodium
Endothal-disodium
disodium (1Ξ,2Ξ,3Ξ,4Ξ)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate
Endothall sodium
Endothall disodium salt
Caswell No. 421C
endothall sodium
Ripenthol
Natriicantharidas
Aguathol

Biological Activity

[Description]:

Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Metabolic Disease

[In Vitro]

Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1]. Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1]. Cell Viability Assay[1] Cell Line: HCC cell lines (SMMC-7721 and Bel-7402) Concentration: 0-100 μM Incubation Time: 0, 12, 24, 48 or 72 hours Result: Showed anti-proliferative activity in the two HCC cell lines. Cell Viability Assay[1] Cell Line: HCC cells Concentration: 0, 9, 18 or 36 µM Incubation Time: 24 hours Result: Induced apoptosis in HCC cells via the intrinsic pathway.

[In Vivo]

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1].

[References]

[1]. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15.

Chemical & Physical Properties

[ Boiling Point ]:
447.8ºC at 760 mmHg

[ Molecular Formula ]:
C8H8Na2O5

[ Molecular Weight ]:
230.13

[ Flash Point ]:
190.5ºC

[ Exact Mass ]:
230.01700

[ PSA ]:
89.49000

[ Vapour Pressure ]:
2.88E-09mmHg at 25°C

Safety Information

[ Risk Phrases ]:
21-25-36/37/38

[ RIDADR ]:
UN 2588

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

DownStream

Related Compounds