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SCD1 inhibitor-4

Names

[ CAS No. ]:
1295541-87-5

[ Name ]:
SCD1 inhibitor-4

Biological Activity

[Description]:

SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD)
Research Areas >> Metabolic Disease

[Target]

SCD1[1]


[In Vivo]

SCD1 inhibitor-4 (1~30 mg/kg) shows a dose-dependent decrease in desaturation index with a 55 % reduction at 1 mg/kg and 85% reduction at the 10 and 30 mg/kg doses[1].

[References]

[1]. Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011;21(6):1621-1625.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H16F3N5O

[ Molecular Weight ]:
363.34

Related Compounds