<Suppliers Price>

Yangambin

Names

[ CAS No. ]:
13060-14-5

[ Name ]:
Yangambin

[Synonym ]:
Lirioresinol B dimethyl ether
Lirioresinol B,O,O-dimethyl
syringaresinol dimethyl ether
Lirioresinol B,dimethyl
O,O-Dimethyllirioresinol B

Biological Activity

[Description]:

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cardiovascular Disease
Research Areas >> Infection

[Target]

Ca2+


[References]

[1]. Araújo IG, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19(5):6863-76.

[2]. Jindaporn Puripattanavong, et al. Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves. Songklanakarin J. Sci. Technol. 2015,37 (1), 37-41.

Chemical & Physical Properties

[ Density]:
1.183g/cm3

[ Boiling Point ]:
556.1ºC at 760 mmHg

[ Molecular Formula ]:
C24H30O8

[ Molecular Weight ]:
446.49000

[ Flash Point ]:
221.1ºC

[ Exact Mass ]:
446.19400

[ PSA ]:
73.84000

[ LogP ]:
3.81340

[ Vapour Pressure ]:
7.78E-12mmHg at 25°C

[ Index of Refraction ]:
1.537

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds