RP-001
Names
[ CAS No. ]:
1306761-53-4
[ Name ]:
RP-001
Biological Activity
[Description]:
RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].
[Related Catalog]:
[In Vitro]
RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels[1].
[In Vivo]
RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C24H24N4O4
[ Molecular Weight ]:
468.93300
[ Exact Mass ]:
468.15600
[ PSA ]:
121.27000
[ LogP ]:
5.30698