(R)-Propranolol hydrochloride

Names

[ Name ]:
(R)-Propranolol hydrochloride

[Synonym ]:
EINECS 235-961-7
MFCD00066275
(R)-(+)-PROPRANOLOL
(R)-Propranolol Hydrochloride

Biological Activity

[Description]:

(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[In Vivo]

Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol is 0.09 mg/kg whereas that of (+)-propranolol is 4.2 mg/kg[1]. Both isomers of propranolol are capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs. The dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[1]. (R)-Propranolol hydrochloride (10 mg/kg) has no antagonistic activity in rats, the cardiac responses to isoprenaline of rat can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[1].

[References]

[1]. A M Barrett,et al. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol

Chemical & Physical Properties

[ Boiling Point ]:
434.9ºC at 760 mmHg

[ Melting Point ]:
196-198 °C(lit.)

[ Molecular Formula ]:
C₁₆H₂₂ClNO₂

[ Molecular Weight ]:
295.80400

[ Flash Point ]:
216.8ºC

[ Exact Mass ]:
295.13400

[ PSA ]:
41.49000

[ LogP ]:
3.77040

[ Vapour Pressure ]:
2.48E-08mmHg at 25°C

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 10 mg/mL

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen.

Anal. Bioanal. Chem 396 , 649-56, (2010)

Environmental risk assessments of human pharmaceuticals and other 'emerging contaminants' should integrate both population-relevant endpoints and biomarkers of potential modes of action in a range of ...