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Acid-PEG5-mono-methyl ester

Names

[ CAS No. ]:
1309460-30-7

[ Name ]:
Acid-PEG5-mono-methyl ester

[Synonym ]:
3-Oxo-2,6,9,12,15,18-hexaoxahenicosan-21-oic acid
MFCD18916990
4,7,10,13,16-Pentaoxanonadecane-1,19-dioic acid, monomethyl ester

Biological Activity

[Description]:

Acid-PEG5-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
469.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H28O9

[ Molecular Weight ]:
352.377

[ Flash Point ]:
161.3±22.2 °C

[ Exact Mass ]:
352.173340

[ LogP ]:
-1.44

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.459

Related Compounds