<Suppliers Price>

Tubulin inhibitor 7

Names

[ CAS No. ]:
1309925-41-4

[ Name ]:
Tubulin inhibitor 7

Biological Activity

[Description]:

Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

IC50: 0.52 μM (tubulin polymerization)[1]


[In Vitro]

Tubulin inhibitor 7 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1]. Tubulin inhibitor 7 shows excellent antiproliferative potencies with IC50s of 40, 24, 16, 6, 29, and 16 nM for NCIH460, SKOV3, BT549, 451LU, SW480, and DLD-1 tumor cell lines, recpectively[1].

[References]

[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14N2O4

[ Molecular Weight ]:
358.35

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds