MPC-0767
Names
[ CAS No. ]:
1310540-32-9
[ Name ]:
MPC-0767
Biological Activity
[Description]:
MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability[1].
[Related Catalog]:
[Target]
HSP90
[In Vivo]
MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the Tmax, Cmax, AUC and F% are 1 (h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively[1]. MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals[1]. MPC-0767 is well tolerated when administered at 252 mg/kg po (equivalent to 200 mg/kg dose of MPC-3100)[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H36BrN7O9S2
[ Molecular Weight ]:
734.64