Hydrazinocurcumin

Names

[ Name ]:
Hydrazinocurcumin

[Synonym ]:
hydrazinocurcumin
(E)-3,5-bis[β-(4-hydroxy-3-methoxyphenyl)-ethenyl]-1H-pyrazole
4,4'-[1H-Pyrazole-3,5-diyldi(E)-2,1-ethenediyl]bis(2-methoxyphenol)
Phenol, 4,4'-[1H-pyrazole-3,5-diyldi(E)-2,1-ethenediyl]bis[2-methoxy-
4,4'-[1H-Pyrazole-3,5-diyldi(E)ethene-2,1-diyl]bis(2-methoxyphenol)

Biological Activity

[Description]:

Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets; suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis; inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.

[References]

References 1. Shim JS, et al. Bioorg Med Chem. 2002 Sep;10(9):2987-92. 2. Shim JS, et al. Bioorg Med Chem. 2002 Aug;10(8):2439-44. 3. Wang X, et al. Int J Oncol. 2012 Apr;40(4):1189-95. View Related Products by Target STAT

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
621.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₀N₂O₄

[ Molecular Weight ]:
364.395

[ Flash Point ]:
329.4±31.5 °C

[ Exact Mass ]:
364.142303

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.748