S-Acetyl-PEG3-azide

Names

[ Name ]:
S-Acetyl-PEG3-azide

[Synonym ]:
Ethanethioic acid, S-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl] ester
S-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl) ethanethioate
MFCD22201539

Biological Activity

[Description]:

S-Acetyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₉N₃O₄S

[ Molecular Weight ]:
277.341

[ Exact Mass ]:
277.109619

[ LogP ]:
0.31

S-Acetyl-PEG3-azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds