Efaproxiral

Names

[ Name ]:
Efaproxiral

[Synonym ]:
2-Dacmpp
Efaproxyn
2-[4-((((3,5-dimethylphenyl)-amino)carbonyl)methyl)phenoxy]-2-methyl propionic acid
RSR13
2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid
Efaproxiral
2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid
Efaproxiral Sodium

Biological Activity

[Description]:

Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[References]

[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.202g/cm3

[ Boiling Point ]:
554.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₃NO₄

[ Molecular Weight ]:
341.40100

[ Flash Point ]:
289.2ºC

[ Exact Mass ]:
341.16300

[ PSA ]:
75.63000

[ LogP ]:
3.79960

[ Vapour Pressure ]:
3.93E-13mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%