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Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt

Names

[ CAS No. ]:
131334-43-5

[ Name ]:
Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt

[Synonym ]:
LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT)
MYELIN PROTEOLIPID PROTEIN (139-151)
Myelin Proteolipid Protein (139-151) (1)
MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT)
PLP (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT)
PLP (HUMAN,BOVINE,DOG,MOUSE,RAT)
HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN,BOVINE,DOG,MOUSE,RAT)
PLP (139-151)

Biological Activity

[Description]:

PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Peptides

[In Vitro]

Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151)[1].

[In Vivo]

PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28[2]. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease[3].

[References]

[1]. Kuchroo VK, et al. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59(5):305-12.

[2]. Sobel RA, et al. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide ofmyelin proteolipid protein. J Neuropathol Exp Neurol. 1990 Sep;49(5):468-79.

[3]. Bebo BF Jr, et al. Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res. 1996 Sep 15;45(6):680-9.


[Related Small Molecules]

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Chemical & Physical Properties

[ Molecular Formula ]:
C72H104N20O16S

[ Molecular Weight ]:
1537.79000

[ Exact Mass ]:
1536.77000

[ PSA ]:
605.02000

[ LogP ]:
3.97660

[ Storage condition ]:
2-8℃

Related Compounds