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Bis-PEG4-PFP ester

Names

[ CAS No. ]:
1314378-12-5

[ Name ]:
Bis-PEG4-PFP ester

[Synonym ]:
Bis(pentafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
MFCD21363293
4,7,10,13-Tetraoxahexadecane-1,16-dioic acid, bis(2,3,4,5,6-pentafluorophenyl) ester

Biological Activity

[Description]:

Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
570.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H20F10O8

[ Molecular Weight ]:
626.395

[ Flash Point ]:
287.7±25.0 °C

[ Exact Mass ]:
626.099854

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.463

Related Compounds