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PI3Kγ inhibitor 2

Names

[ CAS No. ]:
1315538-79-4

[ Name ]:
PI3Kγ inhibitor 2

Biological Activity

[Description]:

PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a Ki of 4 nM[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Research Areas >> Inflammation/Immunology

[Target]

PI3Kγ:4 nM (Ki)

[References]

[1]. Come JH, et al. Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J Med Chem. 2018 Jun 28;61(12):5245-5256.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₈F₃N₅O₃

[ Molecular Weight ]:
433.38

Related Compounds