Metronidazole Benzoate

Names

[ Name ]:
Metronidazole Benzoate

[Synonym ]:
(E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid
caffeic acid 3-methyl ether
Benzoylmetronildazole
Coniferic acid
(E)-4-hydroxy-3-methoxy-Cinnamic acid
(E)-4-Hydroxy-3-methoxycinnamic acid
MFCD00239523
(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
Metronidazole Benzoate
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
2-Methyl-5-nitro-1H-imidazole-1-ethyl benzoate
Ferulic acid
Ferulic acid, trans-
3-(4-Hydroxy-3-methoxyphenyl)propenoic acid
2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl benzoate
(2E)-3-(4-Hydroxy-3-methoxyphenyl)acrylic acid
EINECS 236-131-7
1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, benzoate (ester)
Ferulic acid, E-

Biological Activity

[Description]:

Metronidazole Benzoate, derives from a metronidazole and a benzoic acid, has a role as an antibacterial, antimicrobial, antiparasitic, and antitrichomonal agent[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Antibacterial, antimicrobial, antiparasitic, antitrichomonal[1]

[In Vitro]

Metronidazole Benzoate is indicated for the treatment of infections caused by a wide range of anaerobic, protozoan and bacteroid bacteria, including trichomoniasis, amebiasis, vaginosis and gingivitis[1].

[References]

[1]. Santiago de Oliveira Y, et al. The design of novel metronidazole benzoate structures: exploring stoichiometric diversity. Acta Crystallogr C Struct Chem. 2019 May 1;75(Pt 5):483-495.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
372.3±27.0 °C at 760 mmHg

[ Melting Point ]:
102 °C

[ Molecular Formula ]:
C₁₃H₁₃N₃O₄

[ Molecular Weight ]:
194.184

[ Flash Point ]:
150.5±17.2 °C

[ Exact Mass ]:
194.057907

[ PSA ]:
89.94000

[ LogP ]:
1.64

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.627

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The treatment of Trichomonas vaginalis vaginitis. An open controlled prospective study comparing a single dose of metronidazole tablets, benzoyl metronidazole suspension and tinidazole tablets.

S. Afr. Med. J. 67(12) , 455-7, (1985)

Metronidazole tablets, benzoyl metronidazole suspension and tinidazole tablets each given as a single 2 g bolus dose in an open controlled prospective study were found to be effective forms of treatme...

Use of Klion suspension in paediatry and gynaecology.

Ther. Hung. 40(4) , 189-91, (1992)

Klion suspension was given to 42 girl and woman patients suffering from vaginal trichomoniasis. Negativity for Trichomonas was recorded in 73.8% of the cases in response to the first 10-day cure, and ...

Trichomonas infection in pregnancy--does it affect perinatal outcome?

S. Afr. Med. J. 63(15) , 566-7, (1983)

Antenatal patients free of Trichomonas vaginalis vaginal infection were compared with infected patients, half of whom were treated and half left untreated. The treated group was given benzoylmetronida...