Spinosad

Names

[ CAS No. ]:
131929-60-7

[ Name ]:
Spinosad

[Synonym ]:
RAMOPLANIN
SPINOSYN A
(5aR,5bS,14R,16bR)-13-{[5-(Dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methylhexopyranoside
1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-methylhexopyranosyl)oxy]-13-[[5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-, (5aR,5bS,14R,16bR)-
Spinosad
Spinosyn D

Biological Activity

[Description]:

Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Spinosad is a mixture of two natural occurring macrocyclic lactones (spinosyn A and spinosyn D) and acts primarily as a nAChR agonist[2].

[References]

[1]. Hak Joong Kim, et al. Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK. J Am Chem Soc. 2010 Mar 10;132(9):2901-3.

[2]. D T Vo, et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
801.5±65.0 °C at 760 mmHg

[ Melting Point ]:
84ºC to 99.5ºC

[ Molecular Formula ]:
C₄₁H₆₅NO₁₀

[ Molecular Weight ]:
731.956

[ Flash Point ]:
438.5±34.3 °C

[ Exact Mass ]:
731.460876

[ PSA ]:
111.22000

[ LogP ]:
4.80

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.540

Safety Information

[ RIDADR ]:
UN 3077

[ Packaging Group ]:
III

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%