Oil Red O

Names

[ Name ]:
Oil Red O

[Synonym ]:
2-Naphthalenol, 1-[(E)-2-[4-[(E)-2-(2,5-dimethylphenyl)diazenyl]-2,5-dimethylphenyl]diazenyl]-
1-(2,5-Dimethyl-4-(2,5-dimethylphenylazo)phenylazo)-2-naphthol
Oil red O(C.1.26125)
EINECS 215-295-3
MFCD00003898
Solvent Red 27 Sudan Red 5B
Oil Red O
1-[(E)-{4-[(E)-(2,5-Dimethylphenyl)diazenyl]-2,5-dimethylphenyl}diazenyl]-2-naphthol
1-((4-((2,5-Dimethylphenyl)diazenyl)-2,5-dimethylphenyl)diazenyl)naphthalen-2-ol

Biological Activity

[Description]:

Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Mehlem A, et al. Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease. Nat Protoc. 2013 Jun;8(6):1149-54.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
638.8±55.0 °C at 760 mmHg

[ Melting Point ]:
120ºC

[ Molecular Formula ]:
C₂₆H₂₄N₄O

[ Molecular Weight ]:
408.495

[ Flash Point ]:
439.7±20.8 °C

[ Exact Mass ]:
408.195007

[ PSA ]:
69.67000

[ LogP ]:
7.58

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.631

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319-H336

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,Xi

[ Risk Phrases ]:
36/37/38-67-36-11

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
1993.0

[ WGK Germany ]:
3

[ Hazard Class ]:
3.0

[ HS Code ]:
32041900

Customs

[ HS Code ]: 32041900

Articles

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.

Proc. Natl. Acad. Sci. U. S. A. 111(37) , E3880-9, (2014)

Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is ...

Autophagy facilitates secretion and protects against degeneration of the Harderian gland.

Autophagy 11(2) , 298-313, (2015)

The epithelial derived Harderian gland consists of 2 types of secretory cells. The more numerous type A cells are responsible for the secretion of lipid droplets, while type B cells produce dark granu...

The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue.

Analyst 140(7) , 2224-35, (2015)

We have studied live non-malignant (MCF10A), mildly malignant (MCF7) and malignant (MDA-MB-231) breast cancer cells and human breast cancer tissue. We demonstrate the first application of Raman imagin...