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(E/Z)-Zotiraciclib hydrochloride

Names

[ CAS No. ]:
1321626-25-8

[ Name ]:
(E/Z)-Zotiraciclib hydrochloride

Biological Activity

[Description]:

(E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent CDK2, JAK2, and FLT3 inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK2

JAK2

FLT3

[References]

[1]. William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55(1):169-196.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₅ClN₄O

[ Molecular Weight ]:
408.92

Related Compounds