4-Methylphenyl glycine

Names

[ Name ]:
4-Methylphenyl glycine

[Synonym ]:
MFCD00665357
Glycine, 4-methylphenyl ester
4-Methylphenyl glycinate
Benzeneacetic acid, α-amino-4-methyl-
2-Amino-2-(4-methylphenyl)acetic acid
F2147-0646
2-Amino-2-(p-tolyl)acetic acid
Amino(4-methylphenyl)acetic acid
DL-4-Methylphenylglycine
aminomethylphenylaceticacid
4-Methylphenyl glycine
Amino-p-tolyl-acetic acid

Biological Activity

[Description]:

2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI)[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Kalie A M, et al. Cytosolic Delivery of Proteins by Bioreversible Esterification. JAmChem. 2017. 139(41):14396–14398.

[2]. Finlay MRV, et al. Preparation of 1,3,4-thiadiazole compounds and their use in treating cancer: World Intellectual Property Organization, WO2017093301[P]. 2017-06-08.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
271.0±23.0 °C at 760 mmHg

[ Melting Point ]:
256-257ºC

[ Molecular Formula ]:
C₉H₁₁NO₂

[ Molecular Weight ]:
165.189

[ Flash Point ]:
131.7±20.1 °C

[ Exact Mass ]:
165.078979

[ PSA ]:
63.32000

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.538

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%