CP-96345
Names
[ CAS No. ]:
132746-60-2
[ Name ]:
CP-96345
[Synonym ]:
(2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
CP 96,345
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Tachykinin, Substance P receptor[1]
[References]
Chemical & Physical Properties
[ Density]:
1.15g/cm3
[ Boiling Point ]:
541.5ºC at 760 mmHg
[ Molecular Formula ]:
C28H32N2O
[ Molecular Weight ]:
412.57
[ Flash Point ]:
281.3ºC
[ Exact Mass ]:
412.25100
[ PSA ]:
24.50000
[ LogP ]:
5.40850
[ Vapour Pressure ]:
8.65E-12mmHg at 25°C
[ Index of Refraction ]:
1.633
[ Storage condition ]:
-20°C
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335-H400
[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ RIDADR ]:
UN 3077 9 / PGIII
Articles
Br. J. Pharmacol. 172(3) , 924-39, (2015)
Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administr...
Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008)
This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative str...
An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.Am. J. Pathol. 169(5) , 1663-70, (2006)
Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or p...