Rifamycin,3-[(1-piperazinylimino)methyl]-
Names
[ CAS No. ]:
13292-45-0
[ Name ]:
Rifamycin,3-[(1-piperazinylimino)methyl]-
[Synonym ]:
4-N-Demethylrifampicin
rifaldehyde piperazin-1-ylhydrazone
Rifampicin AF/AP
3-(piperazin-1-ylimino-methyl)-rifamycin
N-Demethylrifampin
AF/AP
N-Demethylrifampicin
Rifampicin AF/A
3-(piperidinyliminomethyl)rifamycin SV
Demethylrifampicin
Chemical & Physical Properties
[ Density]:
1.35g/cm3
[ Molecular Formula ]:
C42H56N4O12
[ Molecular Weight ]:
808.91400
[ Exact Mass ]:
808.38900
[ PSA ]:
228.94000
[ LogP ]:
4.39790
[ Index of Refraction ]:
1.631
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KD1923000
- CHEMICAL NAME :
- 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl -8-(N-1-piperazinylfo rmimidoyl)-, 21- acetate
- CAS REGISTRY NUMBER :
- 13292-45-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C42-H56-N4-O12
- MOLECULAR WEIGHT :
- 809.02
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 695 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 60,96,1974