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Maprotiline-d3 (hydrochloride)

Names

[ CAS No. ]:
1329496-63-0

[ Name ]:
Maprotiline-d3 (hydrochloride)

[Synonym ]:
9,10-Ethanoanthracene-9(10H)-propanamine, N-(methyl-d3)-, hydrochloride (1:1)
N-(2H3)Methyl-3-(tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaen-1-yl)-1-propanamine hydrochloride (1:1)

Biological Activity

[Description]:

Maprotiline-d3 (hydrochloride) is deuterium labeled Maprotiline (hydrochloride).

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8.

[3]. http://en.wikipedia.org/wiki/Maprotiline

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21D3ClN

[ Molecular Weight ]:
316.88

[ Exact Mass ]:
316.178558

Related Compounds