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Dronedarone-d6 (hydrochloride)

Names

[ CAS No. ]:
1329809-23-5

[ Name ]:
Dronedarone-d6 (hydrochloride)

[Synonym ]:
N-[2-Butyl-3-(4-{[3-(dibutylamino)(2H6)propyl]oxy}benzoyl)-1-benzofuran-5-yl]methanesulfonamide hydrochloride (1:1)
Methanesulfonamide, N-[2-butyl-3-[4-[[3-(dibutylamino)propyl-1,1,2,2,3,3-d6]oxy]benzoyl]-5-benzofuranyl]-, hydrochloride (1:1)
Dronedarone-d6 (hydrochloride)

Biological Activity

[Description]:

Dronedarone D6 hydrochloride is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120(7):636-44.

[3]. Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2):115-122.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H39D6ClN2O5S

[ Molecular Weight ]:
599.254

[ Exact Mass ]:
598.311401

Related Compounds