2-Diethylaminoethyl 4-amino-2-chloro-benzoate

Names

[ CAS No. ]:
133-16-4

[ Name ]:
2-Diethylaminoethyl 4-amino-2-chloro-benzoate

[Synonym ]:
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
Chloroprocainum
Piocaine
Chloroprocain
Nesacaine
Chlorprocain
2-Chloroprocaine
Halestyn
Chlorprocainum
Chlorprocaine
CHLOROPROCAINE

Biological Activity

[Description]:

Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1].

[Target]

IC50: 13 mM (Na,K-ATPase)[1]

[In Vivo]

In mice, the intravenous LD50 of Chloroprocaine HCl is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine HCl is 950 mg/kg[2].

[References]

[1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.

[2]. Chloroprocaine HCl Injection.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
402.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₂₀Cl₂N₂O₂

[ Molecular Weight ]:
307.21600

[ Flash Point ]:
197.3ºC

[ Exact Mass ]:
306.09000

[ PSA ]:
55.56000

[ LogP ]:
3.80400

[ Vapour Pressure ]:
1.08E-06mmHg at 25°C

[ Index of Refraction ]:
1.553

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575100

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 133-16-4

BEILSTEIN REFERENCE NO. :: 2808071

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H19-Cl-N2-O2

MOLECULAR WEIGHT :: 270.79

WISWESSER LINE NOTATION :: ZR CG DVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9329 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 48 (estimated) No. of Female Employees: 48 (estimated)

Safety Information

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%