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9-cis-β-Carotene

Names

[ CAS No. ]:
13312-52-2

[ Name ]:
9-cis-β-Carotene

[Synonym ]:
neo U-|A-Carotene
β,β-Carotene, (9cis)-
9-cis-|A,|A-Carotene
9-CIS-BETA-CAROTENE
(9cis)-β,β-Carotene
Neo-|A-carotene U
9-cis-|A-Carotene

Biological Activity

[Description]:

9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

9-cis-β-Carotene (1 μM; 18 hours) formulates with the Miglyol 810 and the“antioxidant mix” is incubated to eye cups. The eye cups are isolated from the neuro-retina attached to the underlying RPE tissue from RPE65rd12 mouse. It prevents S- and M-cones degeneration and leads to over 2- and 9- fold higher m-opsin and s-opsin positive staining compares to the control group[1].

[In Vivo]

In a mouse model of retinoid cycle defect, RPE65rd12. Mice with an extract of Dunaliella Bardawil algae rich in 9-cis-β-Carotene (9CBC) rescues retinal function and preserves cone structure by oral administration[1].

[References]

[1]. Sher I, et al.Synthetic 9-cis-beta-carotene inhibits photoreceptor degeneration in cultures of eye cups from rpe65rd12 mouse model of retinoid cycle defect.Sci Rep. 2018 Apr 17;8(1):6130.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
654.7±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C40H56

[ Molecular Weight ]:
536.873

[ Flash Point ]:
346.0±17.2 °C

[ Exact Mass ]:
536.438232

[ LogP ]:
15.51

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.566

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds