GR 73632

[Description]:

GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

IC50: NK-1 receptor[1]

[References]

[1]. Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4.

[2]. Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4.

[ Density]:
1.198g/cm3

[ Boiling Point ]:
1082.2ºC at 760mmHg

[ Molecular Formula ]:
C₄₀H₅₉N₇O₆S

[ Molecular Weight ]:
766.00500

[ Flash Point ]:
608.3ºC

[ Exact Mass ]:
765.42500

[ PSA ]:
222.33000

[ LogP ]:
4.66890

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

Neurokinin receptor modulation of respiratory activity in the rabbit.

Eur. J. Neurosci. 27(12) , 3233-43, (2008)

The respiratory role of neurokinin (NK) receptors was investigated in alpha-chloralose-urethane-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinject...

Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.

Neuropharmacology 55(8) , 1405-11, (2008)

The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmuno...

Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.

Clin. Cancer Res. 12(13) , 4112-8, (2006)

Intestinal toxicity is important in the therapeutic use of radiation as well as in nontherapeutic radiation exposure scenarios. Enteric sensory nerves are critical for mucosal homeostasis and for an a...

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Articles

Related Compounds