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CX-5011

Names

[ CAS No. ]:
1333382-30-1

[ Name ]:
CX-5011

[Synonym ]:
UNII-2F5JG09KS6
Pyrimido(4,5-C)quinoline-8-carboxylic acid,5-((3-ethynylphenyl)amino)-,sodium salt (1:1)
CX-5011

Biological Activity

[Description]:

CX-5011 is a CK2 inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras
Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase
Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[References]

[1]. D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118807.  

[2]. Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H11N4NaO2

[ Molecular Weight ]:
362.31700

[ Exact Mass ]:
362.07800

[ PSA ]:
90.83000

[ LogP ]:
2.33940

Related Compounds