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Z-LLY-FMK

Names

[ CAS No. ]:
133410-84-1

[ Name ]:
Z-LLY-FMK

[Synonym ]:
Calpain Inhibitor IV
Z-Leu-Leu-Tyr-Fluoromethylketone
Z-LLY-FMK
Z-Leu-Leu-Tyr-FMK
IN1508
benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-4-fluoro-1-(4-hydroxyphenyl)-3-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
FK017

Biological Activity

[Description]:

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[Target]

Calpain[1]


[References]

[1]. Sheen-Chen SM, et al. Z-LLY-FMK attenuates intestinal apoptosis after bile duct ligation in rats. Dig Dis Sci. 2009 Nov;54(11):2357-61.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H40FN3O6

[ Molecular Weight ]:
557.65

[ Exact Mass ]:
557.29000

[ PSA ]:
144.30000

[ LogP ]:
5.71510

Related Compounds