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ASS234

Names

[ CAS No. ]:
1334106-34-1

[ Name ]:
ASS234

[Synonym ]:
ASS234
N-({5-[3-(1-Benzyl-4-piperidinyl)propoxy]-1-methyl-1H-indol-2-yl}methyl)-N-methyl-2-propyn-1-amine
1H-Indole-2-methanamine, N,1-dimethyl-5-[3-[1-(phenylmethyl)-4-piperidinyl]propoxy]-N-2-propyn-1-yl-

Biological Activity

[Description]:

ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively; inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro; completely blocks the aggregation mediated by AChE of both Aβ1-42 and Aβ1-40, showing a dual binding site to AChE; ASS234 significantly reduces Aβ1-42-mediated toxicity in SH-SY5Y human neuroblastoma cells, ASS234 is a promising multitarget drug candidates with potential impact for Alzheimer's disease.

[References]

References 1. Bolea I, et al. J Med Chem. 2011 Dec 22;54(24):8251-70. 2. Bolea I, et al. Curr Alzheimer Res. 2013 Oct;10(8):797-808. 3. del Pino J, et al. CNS Neurosci Ther. 2014 Jun;20(6):568-70. 4. Marco-Contelles J, et al. Front Neurosci. 2016 Jun 28;10:294. View Related Products by Target Monoamine Oxidase (MAO)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
582.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H37N3O

[ Molecular Weight ]:
443.624

[ Flash Point ]:
306.1±28.7 °C

[ Exact Mass ]:
443.293671

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.573

Related Compounds