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m-PEG8-Mal

Names

[ CAS No. ]:
1334169-90-2

[ Name ]:
m-PEG8-Mal

[Synonym ]:
1H-Pyrrole-1-propanamide, 2,5-dihydro-N-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl-2,5-dioxo-
3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)propanamide

Biological Activity

[Description]:

m-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
659.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H42N2O11

[ Molecular Weight ]:
534.597

[ Flash Point ]:
352.3±31.5 °C

[ Exact Mass ]:
534.278870

[ LogP ]:
-3.50

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.489

Related Compounds