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Boc-NH-PEG8-CH2CH2COOH

Names

[ CAS No. ]:
1334169-93-5

[ Name ]:
Boc-NH-PEG8-CH2CH2COOH

[Synonym ]:
2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23,26,29-nonaoxa-5-azadotriacontan-32-oic acid
3,8,11,14,17,20,23,26,29-Nonaoxa-5-azadotriacontan-32-oic acid, 2,2-dimethyl-4-oxo-
MFCD13185254
t-Boc-N-amido-PEG8-acid

Biological Activity

[Description]:

Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
627.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H47NO12

[ Molecular Weight ]:
541.630

[ Flash Point ]:
333.4±31.5 °C

[ Exact Mass ]:
541.309814

[ LogP ]:
-1.58

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.468

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds