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Biotin-PEG7-amine

Names

[ CAS No. ]:
1334172-76-7

[ Name ]:
Biotin-PEG7-amine

[Synonym ]:
MFCD21363308

Biological Activity

[Description]:

Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.151±0.06 g/cm3

[ Boiling Point ]:
785.9±60.0 °C

[ Molecular Formula ]:
C26H50N4O9S

[ Molecular Weight ]:
594.7616

[ Storage condition ]:
-20°C

Related Compounds