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S-Acetyl-PEG8-OH

Names

[ CAS No. ]:
1334177-81-9

[ Name ]:
S-Acetyl-PEG8-OH

[Synonym ]:
MFCD13185027
Ethanethioic acid, S-(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl) ester
S-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl) ethanethioate

Biological Activity

[Description]:

S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
512.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H36O9S

[ Molecular Weight ]:
428.538

[ Flash Point ]:
263.6±30.1 °C

[ Exact Mass ]:
428.208008

[ LogP ]:
-2.13

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.478

Related Compounds