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Isovalerylcarnitine-d9 chloride

Names

[ CAS No. ]:
1334532-23-8

[ Name ]:
Isovalerylcarnitine-d9 chloride

[Synonym ]:
(2R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium-d9 Chloride
(2R)-3-Carboxy-N,N,N-tris[(2H3)methyl]-2-[(3-methylbutanoyl)oxy]-1-propanaminium chloride
1-Propanaminium, 3-carboxy-N,N,N-tri(methyl-d3)-2-(3-methyl-1-oxobutoxy)-, chloride (1:1), (2R)-
1-Propanaminium, 3-carboxy-N,N,N-tri(methyl-d3)-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)- (1:1)
(R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium-d9 Chloride

Biological Activity

[Description]:

Isovalerylcarnitine-d9 (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H15D9ClNO4

[ Molecular Weight ]:
290.83

[ Exact Mass ]:
290.195862

Related Compounds