L-Aspartic acid β-(7-amido-4-methylcoumarin)

Names

[ Name ]:
L-Aspartic acid β-(7-amido-4-methylcoumarin)

[Synonym ]:
h-asp(amc)-oh

Biological Activity

[Description]:

H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Hatanaka T, et al. Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.

Chemical & Physical Properties

[ Density]:
1.452g/cm3

[ Boiling Point ]:
610ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₄N₂O₅

[ Molecular Weight ]:
290.27100

[ Flash Point ]:
322.7ºC

[ Exact Mass ]:
290.09000

[ PSA ]:
122.63000

[ LogP ]:
1.61520

[ Vapour Pressure ]:
9.8E-16mmHg at 25°C

[ Index of Refraction ]:
1.651

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

Articles

Applications of a new fluorimetric enzyme assay for the diagnosis of aspartylglucosaminuria.

J. Inherit. Metab. Dis. 16 , 929-934, (1993)

L-Aspartic acid-beta-7-amido-4-methylcoumarin is a sensitive and specific fluorogenic substrate for lysosomal glycoasparaginase (aspartylglucosaminidase). Fibroblasts and leukocytes from 8 patients wi...

Structural basis of aspartylglucosaminuria.

Biochem. Biophys. Res. Commun. 377 , 1168-1172, (2008)

To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modelin...

Enzymatic diagnosis of aspartylglycosaminuria by fluorometric assay of glycosylasparaginase in serum, plasma, or lymphocytes.

Clin. Chem. 40 , 385-388, (1994)

Serum, plasma, and lymphocytes from aspartylglycosaminuria (AGU) patients and carriers and from normal controls were incubated with a fluorescent glycosylasparaginase substrate, L-aspartic acid beta-(...