<Suppliers Price>

PERK-IN-3

Names

[ CAS No. ]:
1337532-08-7

[ Name ]:
PERK-IN-3

Biological Activity

[Description]:

PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> PERK

[Target]

IC50: 7.4 nM (PERK)[1]

[References]

[1]. Axten JM , et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.

Chemical & Physical Properties

[ Density]:
1.446±0.06 g/cm3(Predicted)

[ Boiling Point ]:
694.8±55.0 °C(Predicted)

[ Molecular Formula ]:
C₂₂H₁₆F₂N₄O₂

[ Molecular Weight ]:
406.38

[ Storage condition ]:
-20°C

Related Compounds