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ATI-2341 TFA

Names

[ CAS No. ]:
1337878-62-2

[ Name ]:
ATI-2341 TFA

[Synonym ]:
N-Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine
L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-

Biological Activity

[Description]:

ATI-2341 is a CXCR4 agonist, induces CXCR4-dependent calcium flux, with an EC50 of 194 nM in CCRF-CEM cells. ATI-2341 is also a potent and efficacious mobilizer of bone marrow hematopoietic cells[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR
Research Areas >> Metabolic Disease
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4:194 nM (EC50, in CCRF-CEM cells)


[In Vitro]

ATI-2341 dose-dependently increases intracellular calcium in cells transfected with wild-type CXCR4 (EC50, 140 ± 36 nM)[1].

[References]

[1]. Tchernychev B, et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C104H178N26O25S2

[ Molecular Weight ]:
2256.82

[ Exact Mass ]:
2255.289795

[ LogP ]:
3.81

[ Index of Refraction ]:
1.625

[ Storage condition ]:
-20℃

Related Compounds