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Diazo Biotin-PEG3-azide

Names

[ CAS No. ]:
1339202-33-3

[ Name ]:
Diazo Biotin-PEG3-azide

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[13-[4-[(E)-2-[5-(2-azidoethyl)-2-hydroxyphenyl]diazenyl]phenyl]-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-
Diazo biotin-azide
4-{(E)-[5-(2-Azidoethyl)-2-hydroxyphenyl]diazenyl}-N-{13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadec-1-yl}benzamide
MFCD28334530
Azo biotin-azide

Biological Activity

[Description]:

Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C33H45N9O7S

[ Molecular Weight ]:
711.831

[ Exact Mass ]:
711.316284

[ LogP ]:
1.07

Related Compounds