Dextramycine

Names

[ CAS No. ]:
134-90-7

[ Name ]:
Dextramycine

[Synonym ]:
EINECS 205-161-2

Biological Activity

[Description]:

L-(+)-threo-Chloramphenicol ((+)-Chloramphenicol) is the S,S-stereoisomer of Chloramphenicol (HY-B0239). L-(+)-Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L-(+)-threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. 3rd WG, et, al. The effect of chloramphenicol in intact erythroid cells. J Mol Biol. 1966 Nov 28;21(3):537-53.

[2]. Gordon PA, et, al. Effects of chloramphenicol isomers and erythromycin on enzyme and lipid synthesis induced by oxygen in wild-type and petite yeast. J Bacteriol. 1972 May;110(2):504-10.

Chemical & Physical Properties

[ Density]:
1.547g/cm3

[ Boiling Point ]:
644.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₂Cl₂N₂O₅

[ Molecular Weight ]:
323.13

[ Flash Point ]:
343.8ºC

[ Exact Mass ]:
322.01200

[ PSA ]:
115.38000

[ LogP ]:
1.82310

[ Vapour Pressure ]:
1.63E-17mmHg at 25°C

[ Index of Refraction ]:
1.611

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB6835000

CHEMICAL NAME :: Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p- nitrophenethyl)-, L-threo-(+)-

CAS REGISTRY NUMBER :: 134-90-7

LAST UPDATED :: 199410

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-Cl2-N2-O5

MOLECULAR WEIGHT :: 323.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 500 umol/L

REFERENCE :: BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 78,151,1977

Safety Information

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%