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(E/Z)-AG490

Names

[ CAS No. ]:
134036-52-5

[ Name ]:
(E/Z)-AG490

[Synonym ]:
MFCD00209833

Biological Activity

[Description]:

(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Chemical & Physical Properties

[ Density]:
1.337g/cm3

[ Boiling Point ]:
615.2ºC at 760mmHg

[ Melting Point ]:
215ºC

[ Molecular Formula ]:
C17H14N2O3

[ Molecular Weight ]:
294.30500

[ Flash Point ]:
325.9ºC

[ Exact Mass ]:
294.10000

[ PSA ]:
93.35000

[ LogP ]:
2.71208

[ Storage condition ]:
−20°C

[ Water Solubility ]:
ethanol: 5 mg/mL

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
1

Related Compounds