2-Chloro-N6-methyladenosine

Names

[ CAS No. ]:
13406-50-3

[ Name ]:
2-Chloro-N6-methyladenosine

[Synonym ]:
2-chloro-N6-methyladenosine
(4S,2R,3R,5R)-2-[2-chloro-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Adenosine,2-chloro-N-methyl
2-Chloro-N6-methyladenosin

Biological Activity

[Description]:

2-Chloro-N6-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H14ClN5O4

[ Molecular Weight ]:
315.71

[ Exact Mass ]:
315.07300

[ PSA ]:
125.55000

Related Compounds