ponasterone A

Names

[ Name ]:
ponasterone A

[Synonym ]:
25-Deoxyecdysterone
(2b,3b,5b,22R)-2,3,14,20,22-Pentahydroxycholest-7-en-6-one
ponasterone A
(2β,3β,5β,22R)-2,3,14,20,22-Pentahydroxycholest-7-en-6-one
Cholest-7-en-6-one, 2,3,14,20,22-pentahydroxy-, (2β,3β,5β,22R)-
25-Deoxy-20-hydroxyecdysone
MFCD00272144
(2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

Biological Activity

[Description]:

Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

ecdysone receptor[2]

[In Vitro]

Ponasterone A (1 nM-100 μM) shows significant gene induction activity in CV-1 cells[2].

[In Vivo]

Ponasterone A (3-10 mg; i.p.) produces robust inductions of gene expression in transactivator and reporter mice[2].

[References]

[1]. Hansen KØ, et, al. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules. 2018 Jun 19;23(6):1481.

[2]. Gu Y,et, al. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. J Biol Chem. 2000 Jun 16;275(24):17917-20.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
640.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₄₄O₆

[ Molecular Weight ]:
464.635

[ Flash Point ]:
355.2±28.0 °C

[ Exact Mass ]:
464.313782

[ PSA ]:
118.22000

[ LogP ]:
1.55

[ Vapour Pressure ]:
0.0±4.3 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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