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TBDMS-PEG4-OH

Names

[ CAS No. ]:
134179-40-1

[ Name ]:
TBDMS-PEG4-OH

[Synonym ]:
2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol
4,7,10,13-Tetraoxa-3-silapentadecan-15-ol, 2,2,3,3-tetramethyl-
MFCD25424114

Biological Activity

[Description]:

TBDMS-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
349.6±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H32O5Si

[ Molecular Weight ]:
308.486

[ Flash Point ]:
165.2±23.7 °C

[ Exact Mass ]:
308.201904

[ LogP ]:
1.42

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.441

Related Compounds