DCVC

Names

[ Name ]:
DCVC

[Synonym ]:
DCVC
S-((E)-1,2-Dichlor-vinyl)-L-cystein
S-((E)-1,2-dichloro-vinyl)-L-cysteine
(E)-S-(1,2-Dichloroethenyl)-L-cysteine
L-Cysteine,S-(1,2-dichloroethenyl)-,(E)-(9CI)
ALANINE,3-((1,2-DICHLOROVINYL)THIO)-,(E)-L
L-Cysteine,S-((1E)-1,2-dichloroethenyl)
L-Cysteine,S-(1,2-dichloroethenyl)-,(E)
S-(1,2-dichlorovinyl)-L-cysteine
S-(trans-1,2-Dichlorovinyl)-L-cysteine
S-(1,2-Dichlorovinyl)cysteine

Biological Activity

[Description]:

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> TNF Receptor

Research Areas >> Infection

[References]

[1]. Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6.

[2]. Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65.

[3]. Yoo HS, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78(1):32-49.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.544g/cm3

[ Boiling Point ]:
339.7ºC at 760mmHg

[ Molecular Formula ]:
C₅H₇Cl₂NO₂S

[ Molecular Weight ]:
216.08600

[ Flash Point ]:
159.2ºC

[ Exact Mass ]:
214.95700

[ PSA ]:
88.62000

[ LogP ]:
2.10830

[ Vapour Pressure ]:
1.66E-05mmHg at 25°C

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%