Azido-PEG8-CH2CO2H

Names

[ CAS No. ]:
1343472-07-0

[ Name ]:
Azido-PEG8-CH2CO2H

[Synonym ]:
AZIDE-PEG8-CH2COOH

Biological Activity

[Description]:

N3-PEG8-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Steinmetz NF, et al. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small. 2011 Jun 20;7(12):1664-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₅N₃O₁₀

[ Molecular Weight ]:
453.485

[ Exact Mass ]:
453.232239

[ LogP ]:
-2.88

[ Storage condition ]:
2-8°C

Azido-PEG8-CH2CO2H

Names

Biological Activity

Chemical & Physical Properties

Related Compounds