Amino-PEG12-alcohol

Names

[ Name ]:
Amino-PEG12-alcohol

[Synonym ]:
35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-ol, 35-amino-
Amino-dPEG(R)12-OH
MFCD11041097

Biological Activity

[Description]:

Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
596.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₅₁NO₁₂

[ Molecular Weight ]:
545.661

[ Flash Point ]:
314.6±28.7 °C

[ Exact Mass ]:
545.341125

[ LogP ]:
-4.95

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.467

Amino-PEG12-alcohol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds