ONO4057

Names

[ Name ]:
ONO4057

[Synonym ]:
Benzenepropanoic acid,2-(4-carboxybutoxy)-6-((6-(4-methoxyphenyl)-5-hexenyl)oxy)-,(E)
Ono 4057
5-(2-(2-Carboxyethyl)-3-(6-(4-methoxyphenyl)-5E-hexenyl)oxyphenoxy)valeric acid
Ono-LB-457
ONO4057

Biological Activity

[Description]:

ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

LTB4:0.7 μM (IC50)

[In Vivo]

Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].

[Animal admin]

Inbred male ACI (180 to 210 g) and LEW (200 to 240 g) rats are used as donors and recipients. Liver transplantation is orthotopically performed. ONO4057 dissolved in 7% NaHCO3 or solvent is administered subcutaneously daily after transplantation. Animals are divided into two groups: group I (n=5), 7% NaHCO3 3 mL/kg as controls; group II (n=6), ONO4057 30 mg/kg per day[2].

[References]

[1]. Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75.

[2]. Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340.

[Related Small Molecules]

MK-571 | Zafirlukast | Pranlukast | Nedocromil | AS-35 | LY223982 | Darbufelone mesilate | LM-1484 | Quinotolast sodium | RG-12525 | RS-601 | Tipelukast | CI-949 | CP 105696 | CP-96486

Chemical & Physical Properties

[ Density]:
1.173g/cm3

[ Boiling Point ]:
704.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₇H₃₄O₇

[ Molecular Weight ]:
470.55500

[ Flash Point ]:
233.1ºC

[ Exact Mass ]:
470.23000

[ PSA ]:
102.29000

[ LogP ]:
5.60860

[ Vapour Pressure ]:
7.52E-21mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
2-8℃