α2β1 Integrin Recognition Sequence

Names

[ Name ]:
α2β1 Integrin Recognition Sequence

[Synonym ]:
L-|A-Aspartylglycyl-L-|A-glutamyl-L-alanine
|A2|A1 Integrin Recognition Sequence
H-Asp-Gly-Glu-Ala-OH
DGEA

Biological Activity

[Description]:

α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cytoskeleton >> Integrin

[References]

[1]. Graham KL, et al. Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequences. J Virol. 2004 Nov;78(21):11786-97.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₂N₄O₉

[ Molecular Weight ]:
390.34600

[ Exact Mass ]:
390.13900

[ PSA ]:
235.69000

[ LogP ]:
0.06470

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

J. Biol. Chem. 266 , 7363-7367, (1991)

The alpha 2 beta 1 integrin serves as either a specific cell surface receptor for collagen or as both a collagen and laminin receptor depending upon the cell type. Recently we established that the alp...

RGDS and DGEA-induced [Ca2+]i signalling in human dermal fibroblasts.

Biochim. Biophys. Acta Mol. Cell Res. 1746(1) , 28-37, (2005)

A pulse of short peptides, RGDS and DGEA in the millimolar range, immediately elicits in normal human fibroblasts a transient increase of intracellular Ca2+ ([Ca2+]i). In the present study, we show th...

Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin αV.

PLoS ONE 8 , e59558, (2013)

Glioma initiating cells (GICs) are considered responsible for the therapeutic resistance and recurrence of malignant glioma. To clarify the molecular mechanism of GIC maintenance/differentiation, we e...